[1]陈 怡,王继伟.肌肉减少症与结直肠癌关系的研究进展[J].肠外与肠内营养杂志,2022,(03):184-189.[doi:DOI : 10.16151/j.1007-810x.2022.03.012]
 CHEN Yi,WANG Ji-wei.Research progress on the relationship between sarcopenia and colorectal cancer[J].PARENTERAL & ENTERAL NUTRITION,2022,(03):184-189.[doi:DOI : 10.16151/j.1007-810x.2022.03.012]
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肌肉减少症与结直肠癌关系的研究进展
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《肠外与肠内营养》杂志[ISSN:1007-810X/CN:32-1477/R]

卷:
期数:
2022年03期
页码:
184-189
栏目:
综述
出版日期:
2022-05-10

文章信息/Info

Title:
Research progress on the relationship between sarcopenia and colorectal cancer
作者:
陈 怡王继伟
遵义医科大学附属医院胃肠外科,贵州遵义563000
Author(s):
CHEN Yi WANG Ji-wei
Department of Gastrointestinal Surgery, Affiliated Hospital of Zunyi Medical University, Zunyi 563000, Guizhou, China
关键词:
肌肉减少症 结直肠癌 围术期并发症 化疗副作用
Keywords:
Sarcopenia Colorectal cancer Perioperative complications Chemotherapy side effects Survival prognosis
分类号:
R735.3
DOI:
DOI : 10.16151/j.1007-810x.2022.03.012
文献标志码:
A
摘要:
肌肉减少症是一种以骨骼肌质量和力量的进行性和全身性丧失为特征的综合征,导致身体残疾、生 活质量降低甚至死亡。发生机制涉及炎症和氧化应激、激素水平改变、线粒体功能障碍等。结直肠癌病人肌肉减 少症的发生率在 12% ~ 60% 之间。有研究表明,肌肉减少症可能对 CRC 病人围术期产生负面影响而导致不良临床 结局。本综述结合国内外最新研究进展,系统阐述 CRC 病人肌肉减少症的发生机制、评估方法、以及对围术期并发 症、化疗毒副作用和生存预后的影响,总结并展望 CRC 病人肌肉减少症的干预措施。
Abstract:
Sarcopenia is a syndrome characterized by progressive and systemic loss of skeletal muscle mass and strength, leading to physical disability, reduced quality of life and even mortality. The mechanism of sarcopenia involves inflammation and oxidative stress, changes in hormone levels, and mitochondrial dysfunction. The prevalence of sarcopenia in patients with colorectal cancer (CRC) ranges from 12% to 60%. Studies have shown that sarcopenia may have a negative impact during the perioperative period of CRC surgery and lead to adverse postoperative outcomes. Based on the latest research progress, this review systematically elaborates the mechanism, evaluation methods, and effects of sarcopenia on perioperative complications, toxicity and side effects of chemotherapy and long-term survival in CRC patients, and summarizes and proposes the treatment strategy for sarcopenia in such population.

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备注/Memo

备注/Memo:
基金项目 :国家自然科学基金(81960105),贵州省科学技术基金(黔科合基础[2020]1Y301) 作者简介 :陈 怡,住院医师,医学硕士,主要从事结直肠癌的临床诊疗及研究。E-mail:972023158@qq.com 通讯作者 :王继伟,E-mail:wjw@smail.nju.edu.cn
更新日期/Last Update: 1900-01-01