[1]陈 楹,武音帆,冉 薇,等.口服营养补充对感染奥密克戎变异株的 COVID-19 老年住院病人死亡风险的影响[J].肠外与肠内营养杂志,2023,(04):198-201211.[doi:DOI : 10.16151/j.1007-810x.2023.04.002]
　CHEN Ying,WU Yin-fan,RAN Wei,et al.The effect of oral nutritional supplements on in-hospital mortality inelderly COVID-19 patients with Omicron variant infection[J].PARENTERAL & ENTERAL NUTRITION,2023,(04):198-201211.[doi:DOI : 10.16151/j.1007-810x.2023.04.002]
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口服营养补充对感染奥密克戎变异株的 COVID-19 老年住院病人死亡风险的影响()
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《肠外与肠内营养》杂志[ISSN:1007-810X/CN:32-1477/R]

卷:
期数:
2023年04期
页码:
198-201211
栏目:
论著
出版日期:
2023-08-10

文章信息/Info

Title:
The effect of oral nutritional supplements on in-hospital mortality inelderly COVID-19 patients with Omicron variant infection
作者:
陈 楹1; 武音帆1; 冉 薇1; 袁静珏1; 谈甜甜2; 王 莹1
1. 同济大学附属上海市第四人民医院临床营养科，上海 200434；2. 上海城建职业学院，上海201415
Author(s):
CHEN Ying1;  WU Yin-fan1;  RAN Wei1;  YUAN Jing-jue1;  TAN Tian-tian2;  WANG Ying1
1. Department of Clinical Nutrition, Shanghai Fourth People’s Hospital, School of Medicine, TongjiUniversity, Shanghai 200434, China；2. Shanghai urban construction vocational college, Shanghai201415, China
关键词:
巢式病例对照 ; 口服营养补充 ; 老年病人 ; 奥密克戎变异株 ; 住院期间死亡风险
Keywords:
Nested case-control study;  Oral nutritional supplements;  Elderly patients;  Omicron variant;  Risk ofin-hospital death
分类号:
R459.3，R592
DOI:
DOI : 10.16151/j.1007-810x.2023.04.002
文献标志码:
A
摘要:
目的：探讨口服营养补充（ONS）对感染奥密克戎的老年住院病人死亡风险是否具有降低作用。 方法：回顾性收集 2022 年 4 月 11 日至 6 月 17 日同济大学附属上海市第四人民医院收治入院的奥密克戎感染老年住院病人临床资料，采用巢式病例对照研究方法，选择符合纳入和排除标准的住院期间死亡病人作为死亡组，使用倾向性匹配分析（PSM）方法为死亡组 1:10 匹配对照组。运用单因素和多因素 Logistic 回归分析服用 ONS 和住院期间死亡风险的关系。 结果：本研究纳入死亡组 25 例，对照组 147 例，平均年龄为 86（75, 91）岁。单因素 Logistic 回归结果显示，服用 ONS 相较于未服用 ONS 对感染奥密克戎的老年住院病人死亡风险具有保护作用（OR = 0.29；95%CI:0.12, 0.70; P = 0.006）；多因素 Logistic 回归结果显示，调整混杂后，无论是入院早期（OR = 0.07, 95%CI: 0.01, 0.40,P = 0.003) 或者晚期服用 ONS（OR = 0.09; 95%CI: 0.02, 0.46; P = 0.004），均可以显著降低新冠老年病人住院期间死亡率。 结论：对于奥密克戎感染的老年住院病人，入院后在常规饮食的基础上增加口服营养补充，可以显著降低住院期间死亡风险。
Abstract:
Objective: We aimed to investigate whether initiating oral nutritional supplements (ONS) duringhospitalization was associated with reduced in-hospital mortality in elderly COVID-19 patients with Omicron variantinfection. Methods: Data from confirmed COVID-19 patients from April 11 to June 17 in 2022 admitted to ShanghaiFourth People’s Hospital, one of the designated medical centers for COVID-19 in Shanghai, China were collected. Thecases of in-hospital death and controls were selected after 1:10 propensity score matching (PSM) in the Nest case-controlanalysis. The univariate and multivariate logistic regression models were used to explore the association between ONSand risk of in-hospital death. Results: A total of 25 death cases and 147 controls were selected after PSM. The meanage of included patients was 86 years old (75, 91). The univariate analysis showed that ONS may be a protective factoragainst in-hospital mortality (OR = 0.29；95%CI: 0.12, 0.70; P = 0.006). The multivariate analysis showed that both earlyONS (OR = 0.07, 95%CI: 0.01, 0.40, P = 0.003) and delayed ONS (OR = 0.09; 95%CI: 0.02, 0.46; P = 0.004) couldsignificantly lower risks of in-hospital death in elderly COVID-19 patients. Conclusion: Initiating ONS duringhospitalization could significantly lower risk of in-hospital death in elderly patients with Omicron variant infection.

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备注/Memo

备注/Memo:
基金项目 ：上海市虹口区科学技术委员会医学课题（2102-08）作者简介 ：陈 楹，住院医师，医学硕士，主要研究营养与慢性病。E-mail: chenyemma@163.com通讯作者 ：王 莹，E-mail: 18916484569@163.com
更新日期/Last Update: 1900-01-01