[1]刘坤慧,颜伟慧,蔡 威.肠屏障功能与肠外营养相关肝损伤关系研究进展[J].肠外与肠内营养杂志,2022,(06):370-374.[doi:10.16151/j.1007-810x.2022.06.009]
 LIU Kun-hui,YAN Wei-hui,CAI Wei.Relationship between intestinal barrierfunction and parenteral nutrition associated liver disease[J].PARENTERAL & ENTERAL NUTRITION,2022,(06):370-374.[doi:10.16151/j.1007-810x.2022.06.009]
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肠屏障功能与肠外营养相关肝损伤关系研究进展
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《肠外与肠内营养》杂志[ISSN:1007-810X/CN:32-1477/R]

卷:
期数:
2022年06期
页码:
370-374
栏目:
综述
出版日期:
2022-11-10

文章信息/Info

Title:
Relationship between intestinal barrierfunction and parenteral nutrition associated liver disease
作者:
刘坤慧颜伟慧蔡 威
上海交通大学医学院附属新华医院儿外科,上海200092
Author(s):
LIU Kun-hui YAN Wei-hui CAI Wei
Department of Pediatric Surgery, Xinhua Hospital, Shanghai Jiaotong University Medical School, Shanghai 200092, China
关键词:
肠外营养 肠外营养相关性肝损伤 肠屏障功能 肠上皮细胞 肠道菌群
Keywords:
Parenteral nutrition Parenteral nutrition-associated liver disease Intestinal barrier Intestinal epithelial cell Intestinal microbiota
分类号:
R459.3
DOI:
10.16151/j.1007-810x.2022.06.009
文献标志码:
A
摘要:
肠外营养(PN)为不能经肠内喂养获得充足营养物质的病人提供了营养支持,在临床应用中至关重要。但长期PN的病人会出现如导管相关血流感染、肝功能受损等诸多并发症,其发生机制的根源之一是PN引起的肠屏障功能损伤。近年来相关研究众多,本文对 PN 引起肠屏障功能受损的机制及其在肠外营养相关肝损伤(PNALD)发生发展中的作用做一综述。
Abstract:
Parenteral nutrition (PN)isalifesaving method for adults or children who cannot be provided with sufficient nutrients enterally, and is crucial in clinical practice. However, long-term PN may lead to many complications such as catheter-related bloodstream infectionsand impaired liver function. It is considered that intestinal barrier dysfunction caused by PN is one of the majormechanisms involved in these complications. There have been many studies recently in such field. This paper reviewed the mechanism of intestinal barrier dysfunction caused by PN and its role in the development of parenteral nutrition-associated liver disease (PNALD).

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备注/Memo

备注/Memo:
基金项目 :上海市卫生系统重要薄弱学科建设(2019ZB0101);上海市临床重点专科建设项目(shslczdzk05702);上海市科委基于长三角同质化小儿消化道畸形防治体系研究(19495810500);上海申康医院发展中心临床创新三年行动计划资助(SHDC2020CR2010A) 作者简介 :刘坤慧,医学硕士研究生,主要从事儿外科及消化营养相关研究方向。E-mail:superlkh123@163.com 通讯作者 :蔡 威,E-mail:caiw1978@163.com
更新日期/Last Update: 1900-01-01