[1]朱 骏,潘 杨.帕金森病病人非运动症状与营养不良及风险相关性研究[J].肠外与肠内营养杂志,2022,(01):13-17.[doi:10.16151/j.1007-810x.2022.01.003]
 ZHU Jun,PAN Yang.Relationship between non motor symptoms, malnutrition and risk of malnutrition in patients with Parkinson's disease[J].PARENTERAL & ENTERAL NUTRITION,2022,(01):13-17.[doi:10.16151/j.1007-810x.2022.01.003]
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帕金森病病人非运动症状与营养不良及风险相关性研究
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《肠外与肠内营养》杂志[ISSN:1007-810X/CN:32-1477/R]

卷:
期数:
2022年01期
页码:
13-17
栏目:
论著
出版日期:
2022-01-10

文章信息/Info

Title:
Relationship between non motor symptoms, malnutrition and risk of malnutrition in patients with Parkinson's disease
作者:
朱 骏潘 杨
南京医科大学附属脑科医院 老年医学科,江苏南京 210029
Author(s):
ZHU Jun PAN Yang
Department of Geriatrics, The Affiliated Brain Hospital of Nanjing Medical University, Nanjing 210029, Jiangsu, China
关键词:
帕金森病 营养不良 非运动症状 抑郁
Keywords:
Parkinson’s disease Malnutrition Nonmotor symptoms Depression
分类号:
R742.5
DOI:
10.16151/j.1007-810x.2022.01.003
文献标志码:
A
摘要:
目的:研究帕金森病(PD)病人营养不良的发生率以及与PD非运动症状的关系。 方法:收集356名帕金森病(PD)病人基本信息及用药情况,并通过量表系统性评估运动及非运动症状,利用简易营养评估量表(MNA)评估病人营养状况。 结果:136例PD病人存在营养不良,发生率为38.2%。营养风险病人48例(13.5%)。伴有营养不良及风险的病人,PD-NMS得分较高,除了泌尿道症状、精神症状、性能力减退外,均为伴有营养不良的病人中分项较高(P < 0.05)。HAMD总分在伴营养不良及风险的病人中较高(P < 0.01),提示此组病人有较重的抑郁情绪,且分项比较时提示所有的分项均为存在营养不良或者营养风险的病人中较高。PDSS、HAMA量表比较同样提示在伴有营养不良及风险的病人睡眠质量更差,焦虑情绪更重。Logistic回归分析HAMD-焦虑躯体化(OR =1.954,95%CI:1.539 ~ 2.480,P < 0.001)、HAMD-迟缓(OR = 2.021,95%CI:1.544 ~ 2.646,P < 0.001)、HAMD-睡眠障碍(OR = 1.807,95%CI:1.426 ~ 2.290,P < 0.001)、HAMD-绝望感(OR = 1.826,95%CI:1.391 ~ 2.396,P < 0.001)、NMS-淡漠/注意力减退(OR = 1.428,95%CI:1.003 ~ 2.034,P = 0.048)是营养不良的独立危险因素。 结论:PD病人营养不良的发生与非运动症状密切相关,尤其是抑郁症状,相关病因和发生机制还需要进一步研究。
Abstract:
Objective: This study was designed to assess the incidence of malnutrition in Parkinson’s disease(PD) patients and its association with nonmotor symptoms. Methods: 356 PD patients was recruited for the study. The patient’s nutritional status was assessed using the mini-nutritional assessment (MNA) scale. Results: 38.2% (n = 136) of the PD patients suffered from malnutrition and 13.5% (n = 48) of the PD patients at the risk of malnutrition. Patients at risk of malnutrition and with malnutrition had higher PD-NMS scores, in addition to urinary tract symptoms, mental symptoms and decreased sexual ability, they were all patients with malnutrition Hamilton Depression Scale (HAMD) total score was higher in patients at risk of malnutrition and with malnutrition(P < 0.01), indicating that these patients had severe depression, and the comparison of sub items showed that all sub items were higher in patients with malnutrition or nutritional risk. The sorce of PDSS and HAMA also suggests that patients with malnutrition and risk have worse sleep quality and heavier anxiety. The logistic regression analysis showed that HAMD-Anxiety/somatization (OR= 1.954, 95%CI:1.539 ~ 2.480,P < 0.001), HAMD- Retardation (OR = 2.021, 95%CI:1.544 ~ 2.646, P < 0.0001), HAMD-Sleep disturbances (OR = 1.807, 95%CI:1.426 ~ 2.290, P < 0.001) and HAMD Hopelessness (OR = 1.826, 95%CI:1.391 ~ 2.396, P < 0.001) and NMS-Apathy/attention/memory (OR = 1.428, 95%CI:1.003 ~ 2.034, P = 0.048) were independent risk factors for malnutrition in the PD patients. Conclusions: Our result suggests that the nonmotor symptoms were the main risk factor of malnutrition in PD patients, especially depressive symptoms. The related etiology and pathogenesis still need further study.

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备注/Memo

备注/Memo:
基金项目 :国家自然科学基金青年项目(82171249) 作者简介 :朱 骏,主治医师,医学博士研究生,主要从事运动障碍和睡眠障碍的基础和临床研究。E-mail:1009065726@qq.com 通讯作者 :潘 杨,E-mail:neuro_panyang@163.com
更新日期/Last Update: 1900-01-01