[1]邓凯元,单廷,顾琛,等.益生菌联合早期肠内营养支持对于胃癌病人术后康复的影响[J].肠外与肠内营养杂志,2021,(04):207-210.[doi:10.16151/j.1007-810x.2021.04.004]
　DENG Kai-yuan,SHAN Ting,GU Chen,et al.Effect of combined probiotics and early enteral nutrition on postoperative recovery in patients with gastric cancer[J].PARENTERAL & ENTERAL NUTRITION,2021,(04):207-210.[doi:10.16151/j.1007-810x.2021.04.004]
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益生菌联合早期肠内营养支持对于胃癌病人术后康复的影响
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《肠外与肠内营养》杂志[ISSN:1007-810X/CN:32-1477/R]

卷:
期数:
2021年04期
页码:
207-210
栏目:
论著
出版日期:
2021-07-10

文章信息/Info

Title:
Effect of combined probiotics and early enteral nutrition on postoperative recovery in patients with gastric cancer
作者:
邓凯元1; 单廷 1; 顾琛 1; 渠辉恒 1; 范隽韵 2
南京医科大学附属无锡第二医院，1.普通外科；2.康复医学科，江苏无锡214002
Author(s):
DENG Kai-yuan1;  SHAN Ting1;  GU Chen1;  QU Hui-heng1;  FAN Juan-yun2
1. Department of General Surgery；2. Department of Rehabilitation, Wuxi Second Hospital, Nanjing Medical University. Wuxi 214002,Jiangsu,China
关键词:
胃癌 ; 益生菌 ; 早期肠内营养 ; 术后康复 ; 肠道菌群
Keywords:
Gastric cancer;  Probiotics;  Early enteral nutrition;  Postoperative rehabilitation;  Intestinal flora
分类号:
R459.3，R735.2
DOI:
10.16151/j.1007-810x.2021.04.004
文献标志码:
A
摘要:
目的：研究益生菌联合早期肠内营养支持治疗对于胃癌病人术后康复过程的影响。方法：回顾性分析2019年1月至2021年2月于无锡市第二人民医院接受胃癌根治术的病人共80例，分为对照组（n = 40）和研究组（n = 40）。对照组予以单纯早期肠内营养支持，研究组予以益生菌联合早期肠内营养支持，观察比较两组病人术后营养与炎症指标、肠道菌群、肠道功能恢复情况之间的差异。结果：经过营养治疗后，研究组与对照组病人血清营养指标总蛋白、前白蛋白与白蛋白水平之间无明显差异（P > 0.05），但是研究组血清炎症反应指标C反应蛋白（t = 3.924, P < 0.001）、白细胞介素6（t = 5.269, P < 0.001）与肿瘤坏死因子α（t = 3.251, P = 0.002）水平均显著低于对照组；研究组营养治疗后肠道内双歧杆菌（t = 4.048, P < 0.001）、乳酸杆菌（t = 2.362, P = 0.021）与肠球菌（t = 2.412,P = 0.018）水平均显著高于对照组。此外，研究组术后首次排气时间（t = 5.589, P < 0.001），首次排便时间（t =3.851,P < 0.001），恢复经口饮食时间（t = 4.717, P < 0.001）均显著短于对照组。结论：益生菌联合早期肠内营养支持能够改善肠道菌群失衡，减轻术后炎症反应，同时促进肠道功能的恢复，有利于胃癌病人的术后康复。
Abstract:
Objective: To explore the effect of combined probiotics and early enteral nutrition on the recovery of patients after gastric cancer surgery. Methods: A retrospective analysis including 80 patients undergoing radical gastrectomy at Wuxi second hospital from January 2019 to February 2021 were performed. Patients were divided into the control group (n = 40) and the study group (n = 40). The control group was treated with early enteral nutrition, while the study group was treated with combined probiotics and early enteral nutrition. The outcomes of nutritional and inflammatory markers, intestinal flora, and postoperative intestinal function were observed and compared between the two groups. Results: There were no significant differences in the levels of serum total protein, pre-albumin, and albumin between the 2 groups(P > 0.05), while the levels of serum C-reactive protein (t =3.924, P < 0.001), interleukin-6 (t = 5.269, P < 0.001), and tumor necrosis factor-α (t = 3.251, P = 0.002) in the study group were significantly lower than those in the control group. Additionally, the levels of intestinal Bifidobacterium (t = 4.048, P < 0.001), lactobacillus (t =2.362, P = 0.021), and enterococcus (t = 2.412, P = 0.018) in the study group were significantly elevated compared with those in the control group. Time of passing flatus (t = 5.589, P < 0.001), bowel movement ( t =3.851, P < 0.001), and oral feeding (t = 4.717, P < 0.001) after surgery in the study group were also significantly shorter. Conclusions: Combined probiotics and early enteral nutrition was helpful to improve the intestinal dysbiosis, reduce the postoperative inflammatory response, and restore the intestinal function, leading to te advanced recovery after surgy in patients with gastric cancer.

参考文献/References:


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备注/Memo

备注/Memo:
作者简介 ：邓凯元，住院医师，医学博士，从事普通外科专业。E-mail: leodky1988@ 126.com 通讯作者 ：范隽韵，E-mail: fjy19870722@ sina.com
更新日期/Last Update: 1900-01-01