[1]杨 翔,陈 敏,万文辉,等.肠内营养混悬液(TPF-DM)对超高龄2 型糖尿病病人营养、糖脂代谢及免疫功能的影响[J].肠外与肠内营养杂志,2021,(03):144-146.[doi:10.16151/j.1007-810x.2021.03.004]
 YANG Xiang,CHEN Min,WAN Wen-hui,et al.The effects of enteral nutritional suspension(TPF-DM) on nutrition, glucose and lipid metabolism and immune function in super aged patients with Type 2 diabetes mellitus[J].PARENTERAL & ENTERAL NUTRITION,2021,(03):144-146.[doi:10.16151/j.1007-810x.2021.03.004]
点击复制

肠内营养混悬液(TPF-DM)对超高龄2 型糖尿病病人营养、糖脂代谢及免疫功能的影响
分享到:

《肠外与肠内营养》杂志[ISSN:1007-810X/CN:32-1477/R]

卷:
期数:
2021年03期
页码:
144-146
栏目:
论著
出版日期:
2021-05-10

文章信息/Info

Title:
The effects of enteral nutritional suspension(TPF-DM) on nutrition, glucose and lipid metabolism and immune function in super aged patients with Type 2 diabetes mellitus
作者:
杨 翔陈 敏万文辉贡 歌张 瑗刘 瑜陈阳希张兴虎
东部战区总医院干部病房一科,江苏南京 210002
Author(s):
YANG Xiang CHEN Min WAN Wen-hui GONG Ge ZHANG Yuan LIU Yu CHEN Yang-xi ZHANG Xing-hu
Department of Geriatrics, Genernal Hospital of Eastern Theater Command, PLA, Nanjing 210002 , Jiangsu,China
关键词:
超高龄 肠内营养混悬液 2型糖尿病 营养 糖脂代谢 免疫功能
Keywords:
Super aged Enteral nutritional suspension Type 2 diabetes mellitus Nutrition Glucose and lipid metabolism Immune function
分类号:
R459.3,R587.1
DOI:
10.16151/j.1007-810x.2021.03.004
文献标志码:
A
摘要:
目的:评估肠内营养混悬液(TPF-DM)(diason 0.75 kcal/mL)对超高龄(≥90岁)2型糖尿病病人营养、糖脂代谢及免疫功能的影响。 方法:取42例超高龄老年2型糖尿病病人[90.2 ~ 105.8岁,平均年龄(94.3 ± 5.9)岁]作为研究对象,分别于TPF-DM治疗前及治疗6月后测量其营养MNA评分、体质指数(BMI)、上臂中点围(MAC)、三头肌皮褶厚度(TSF);并于治疗前后分别检测其外周血 ALB、总维生素 D、血红蛋白、HbA1c、TC、TG、LDL-C、CD3+ T 细胞、CD4+ T 细胞、CD8+ T 细胞、CD4+/CD8+和 NK 细胞水平,并比较上述两组指标治疗前后间的差异。结果:与治疗前相比较,超高龄2型糖尿病人给予TPF-DM,6个月后其外周血血红蛋白明显上升(P < 0.05);MNA、BMI、TSF值、ALB、血清总维生素D、CD3+ T细胞、CD4+ T细胞和CD4+/CD8+上升更为显著(P < 0.01);外周血HbA1和TG水平明显下降(P < 0.01)。 结论:超高龄体弱老年糖尿病病人的处于营养不良及免疫功能低下状态,TPF DM能够明显改善其营养、糖脂代谢及免疫功能。
Abstract:
Objective: To evaluate the effect of enteral nutritional suspension (TPF-DM) (diason 0.75 kcal/mL) on nutrition, glucose and lipid metabolism and immune function in super aged patients with type 2 diabetes mellitus (T2DM). Methods: Forty two super aged patients with T2DM [90.2 ~ 105.8 years old, average age (94.3 ± 5.9) years old] were selected as research objects. The nutritional MNA score, BMI, MAC and TSF were measured respectively before and after TPF-DM treatment for six months, and also the levels of peripheral blood ALB, total vitamin D, hemoglobin, HbA1c, TC, TG, LDL-C, CD3+ T cells, CD4 + T cells, CD8+T, CD4+/CD8 + and NK cells were measured respectively. Then the differences were compared between the before and after treatment. Results: Treatmented by TPF DM for six months, the levels of hemoglobin in the peripheral serum of the super aged patients with T2DM were significantly higher(P < 0.05); MNA, BMI, TSF, ALB,total vitamin D an, CD3+ T cells, CD4+ T cells and CD4+/CD8 + were more significantly higher(P < 0.01); and the levels of HbA1 and TG in peripheral blood were significantly lower (P < 0.01)than those before the treatment. Conclusion: The frail super aged patients with T2DM are in a state of malnutrition and low immune function, TPF-DM can significantly improve their nutrition, glucose and lipid metabolism and immune function.

参考文献/References:


[1]张 静.超高龄老人调脂治疗的进展研究.世界最新医学信息文摘,2019,19(84):45-46.
[2] 王玉芬,陈伟伟,张伟丽,等.60岁以上2型糖尿病患者口服降糖药物临床应用分析.中国临床保健杂志,2019,22(5):657-660.
[3] 吕宪玉,刘 淼,李嘉奇,等.80岁以上高龄老年人主要慢性病的疾病谱调查与分析 . 中华老年心脑血管病杂志,2016,18(9):917-919.
[4] 刘 璐,张 野,陈秀风,等.2016—2018年院内感染病例调查分析.传染病信息,2019,32(4):329-332.
[5] 陈万青, 孙可欣,郑荣寿,等.2013年中国恶性肿瘤发病率和死亡率分析.中国肿瘤,2017,26(1):1-7.
[6] 黎介寿.肠内营养—外科临床营养支持的首选途径.肠外与肠内营养,2003,10(3):129-130.
[7] 李 伟,赵 翠,王国玉,等.肠内营养对老年慢性心力衰竭病人营养状态、心功能及炎性因子的影响 . 实用老年医学,2019,33(7):646-649.
[8] Toussaint E, Van Gossum A, Ballarin A, et al. Enteral access in adults.Clin Nutr,2015,34(3):350-358.
[9] 闫凯旋,曹 铖,杨 磊,等.糖尿病专用型肠内营养混悬液对重型脑损伤病人营养指标以及免疫功能的影响.肠外与肠内营养,2018,25(3):76-80.
[10] 邵 渊,衡卫卫,张 馨. 新型糖尿病型肠内营养制剂调节老年重症急性缺血性脑卒中患者免疫功能 . 中华老年医学杂志,2017,36(8):849-853.
[11] Mesejo A,Montejo- Gonzalez JC,Vaquerizo-Alonso C,et al.Diabetes-specific enteral nutritiona formula in hyperglycemic, mechanically ventilated, critically ill patients: a prospective, open-label, blind-randomized, multicenter study. Crit Care, 2015, 19:390-398.

备注/Memo

备注/Memo:
基金项目 :全军保健专项课题(17BJZ17);国家自然科学基金青年项目(81701890) 作者简介 :杨 翔,主治医师,医学硕士,从事老年医学、老年共病及老年危重病的临床研究。E-mail:yangxiangnj1985@sina.com 通讯作者 :张兴虎,E-mail:zhangxh197002@163.com
更新日期/Last Update: 1900-01-01