[1]许丽遐.DHA对APOE4相关阿尔茨海默病影响的研究进展[J].肠外与肠内营养杂志,2021,(01):44-48,54.[doi:DOI : 10.16151/j.1007-810x.2021.01.010]
 XU Li-xia.Research progress on the effect of DHA on apoE4 related Alzheimer's disease[J].PARENTERAL & ENTERAL NUTRITION,2021,(01):44-48,54.[doi:DOI : 10.16151/j.1007-810x.2021.01.010]
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DHA对APOE4相关阿尔茨海默病影响的研究进展
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《肠外与肠内营养》杂志[ISSN:1007-810X/CN:32-1477/R]

卷:
期数:
2021年01期
页码:
44-48,54
栏目:
综述
出版日期:
2021-01-10

文章信息/Info

Title:
Research progress on the effect of DHA on apoE4 related Alzheimer's disease
作者:
许丽遐
石家庄职业技术学院,河北石家庄 050081
Author(s):
XU Li-xia
Shijiazhuang University of Applied Technology, Shijiazhuang 050081, Hebei, China
关键词:
阿尔茨海默病 载脂蛋白 E4 二十二碳六烯酸 磷脂 DHA
Keywords:
Alzheimer's disease Apolipoprotein E4 Docosahexaenoic acid Phospholipids DHA
分类号:
R459.3,R749.16
DOI:
DOI : 10.16151/j.1007-810x.2021.01.010
文献标志码:
A
摘要:
阿尔茨海默病(AD)是导致老年人痴呆的主要原因。除年龄外,载脂蛋白 E (APOE) 4等位基因是散发型 AD最强的危险因素。饮食和补充摄入 n-3脂肪酸 DHA能降低 AD的发病风险和改善 AD症状。但是相关研究也产生了混乱的和不一致的结果。进一步研究发现,对 APOE 4相关 AD病人补充 DHA的效果可能与补充量和时间、补充对象的疾病严重程度和补充的 DHA的形式有关。APOE4携带者在 AD临床症状较轻时大高剂量长时间补充 DHA是降低 AD发病率的有效途径;最好是通过膳食补充磷脂形式的 DHA而不是 DHA膳食补充。
Abstract:
Alzheimer's disease (AD) is a major cause of dementia in the elderly. In addition to age,the apolipoprotein E(APOE)4 allele is the strongest risk factor for sporadic AD. Dietary and supplemental intake of the omega-3 fatty acid docosahexaenoic acid (DHA) reduces the risk of Alzheimer's diseases (AD) and improve symptoms. But studies have also produced mixed and inconsistent results. Further studies have found that the effects of DHA supplementation in APOE4 related AD patients may be related to the amount and time of supplementation, the disease severity, and the form of DHA supplementation. When the clinical symptoms of AD are mild in APOE4 carriers, highdose and longterm DHA supplementation is an effective way to reduce the incidence of AD. It is best to supplement DHA in the form of phospholipids instead of DHA dietary supplements.

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备注/Memo

备注/Memo:
作者简介 :许丽遐,副教授,护理本科,石家庄职业技术学院,从事营养与健康促进研究。E-mail:xlx-gldd@126.com
更新日期/Last Update: 1900-01-01