[1]岳向峰,阚琳玮,李 敏,等.河南省5家三甲医院脂肪乳类药物应用现状调查[J].肠外与肠内营养杂志,2021,(01):21-24.[doi:10.16151/j.1007-810x.2021.01.005]
　YUE Xiang-feng,KAN Lin-wei,LI Min,et al.Investigation on the application status of lipid emulsion drugs in five grade III level A hospitals[J].PARENTERAL & ENTERAL NUTRITION,2021,(01):21-24.[doi:10.16151/j.1007-810x.2021.01.005]
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河南省5家三甲医院脂肪乳类药物应用现状调查
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《肠外与肠内营养》杂志[ISSN:1007-810X/CN:32-1477/R]

卷:
期数:
2021年01期
页码:
21-24
栏目:
论著
出版日期:
2021-01-10

文章信息/Info

Title:
Investigation on the application status of lipid emulsion drugs in five grade III level A hospitals
作者:
岳向峰1; 阚琳玮1; 李 敏1; 郭丽萍2; 杜佩佩3; 聂会娟1; 杜书章1; 张晓坚1
1.郑州大学第一附属医院药学部，河南郑州450052；2.郑州市中心医院药学部，河南郑州450007； 3.南阳市中心医院药学部，河南南阳 473003
Author(s):
YUE Xiang-feng1;  KAN Lin-wei1;  LI Min1;  GUO Li-ping2;  DU Pei-pei3;  NIE Hui-juan1;  DU Shu zhang1;  ZHANG Xiao-jian1
1.Department of pharmacy , the First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, Henan, China；2. Department of pharmacy, Zhengzhou Central Hospital, Zhengzhou 450007, Henan, China；3.Department of pharmacy, Nanyang Central Hospital, Nanyang 473003, Henan, China
关键词:
脂肪乳类药物 ; 单瓶应用 ; 工业化多腔袋 ; 全营养混合液
Keywords:
Nutritional lipid emulsion drugs;  Single-bottle;  Multiple-compartment bag;  Total nutrition admixtures
分类号:
R9
DOI:
10.16151/j.1007-810x.2021.01.005
文献标志码:
A
摘要:
目的：调查三甲医院营养型脂肪乳类药物不同专业间的应用方式现状，为肠外营养制剂的规范应用提供参考依据。 方法：收集河南省5家三甲医院2019年4月至6月期间甘油三酯含量为50 g以上的药品临床应用数据，分析不同专业间脂肪乳类药物应用方式差别，按时间顺序抽取每家医院5%的工业化多腔袋营养处方进行评价。 结果：调查期间5家三甲医院甘油三酯含量为50 g的药品应用总量为61 810例次，其中单瓶方式41 940例次（67.9%）、工业化多腔袋方式15 774例次（25.5%）、全营养混合液方式4 096例次（6.6%），三种方式应用比为10.2：3.9：1。ICU、内科、外科专业单瓶应用比例分别为67.1%、77.2%、64.2%，专业间差异有统计学意义（P < 0.05）。在“全合一”方式应用中，ICU、内科、外科间工业化多腔袋应用比例分别为50.3%、55.0%、91.2%，专业间差异有统计学意义（P < 0.05）。抽取的789份工业化多腔袋营养处方中，无药物添加的有158份（20.0%），至少添加1种营养药物的有631份（80.0%）。添加其他药物后处方的氮量范围3.4 ~ 13.4 g，热氮比范围67 ~ 219 kcal：1 g。 结论：5家三甲医院营养型脂肪乳类药物仍以单瓶方式应用为主，工业化多腔袋应用比例偏低且添加营养药物的现象较为普遍，亟需相关的规范性文件。
Abstract:
Objective: This investigation shows the current application status of nutritional lipid emulsion drugs among different specialties of grade III level A hospitals, and tries to be a reference for the standard application of parenteral nutrition drugs. Methods: Collect the clinical application data (April to June, 2019) of drugs with triglyceride content of more than 50 g in five grade III level A hospitals in Henan Province. Analyze the differences in the application of lipid emulsion drugs among different specialties. Pick up 5% of the multiple-compartment bag prescriptions from each hospital for evaluation. Results: During the investigation period, the total cases number of drug applications with a triglyceride content of 50 g in 5 grade III level A hospitals was 61 810. Among which, 41 940 cases (67.9%) were used with single-bottles, 15 774 cases (25.5%) were used with multiple-compartment bags and 4 096 cases were used as total nutritional mixtures. The application ratio of 3 methods is 10.2:3.9:1. The application ratios of single bottles used in ICU, internal medicine dept. and surgery dept. are respectively 67.1%, 77.2% and 64.2%. In regards to the differences among specialties which are statistically significant (P < 0.05). In the application of the“all-in-one”, the proportions of the multiple compartment bag used in ICU, internal medicine dept. and surgery dept. are respectively 50.3%, 55.0% and 91.2%. In regards to the differences among specialties which are statistically significant (P < 0.05). Among the 789 multiple-compartment bags, 158(20.0%) had no drug added and 631(80.0%) had at least one nutritional drug added. After adding other drugs, the nitrogen content of the parenteral nutrition prescription ranges from 3.4 to 13.4g and the heat-nitrogen ratio ranges from 67 to 219 kcal: 1 g. Conclusion: The single-bottle is still the main application method of lipid emulsion drugs in the five grade III level A hospitals. The application rate of the multiple compartment bag is relatively low and adding nutritional drugs is pretty common. Regulatory documents are urgently needed.

参考文献/References:


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备注/Memo

备注/Memo:
基金项目 ：河南省医学科技公关计划联合共建项目（LHGJ20190278） 作者简介 ：岳向峰，主治医师，医学硕士，主要从事重症病人的临床营养治疗工作。E-mail：yuefeng8357@163.com 通讯作者 ：张晓坚，E-mail：zhxj0524@sina.com
更新日期/Last Update: 1900-01-01