[1]潘 宇,吴伦清.萝卜硫素在临床营养干预中的应用研究进展[J].肠外与肠内营养杂志,2020,(06):372-375.[doi:DOI : 10.16151/j.1007-810x.2020.06.012]
 PAN Yu,WU Lun-qing.Research progress of sulforaphane in clinical nutrition intervention[J].PARENTERAL & ENTERAL NUTRITION,2020,(06):372-375.[doi:DOI : 10.16151/j.1007-810x.2020.06.012]
点击复制

萝卜硫素在临床营养干预中的应用研究进展
分享到:

《肠外与肠内营养》杂志[ISSN:1007-810X/CN:32-1477/R]

卷:
期数:
2020年06期
页码:
372-375
栏目:
综述
出版日期:
2020-11-10

文章信息/Info

Title:
Research progress of sulforaphane in clinical nutrition intervention
作者:
潘 宇吴伦清
广西壮族自治区人民医院营养科,广西南宁530021
Author(s):
PAN Yu WU Lun-qing
Department of Nutrition,Guangxi Zhuang Autonomous Region People's Hospital, Nanning 530021,Guangxi,China
关键词:
萝卜硫素 Nrf2 营养基因组学 细胞保护基因
Keywords:
Sulforaphane Nrf2 Nutrigenomics Cytoprotective genes
分类号:
R459.3
DOI:
DOI : 10.16151/j.1007-810x.2020.06.012
文献标志码:
A
摘要:
萝卜硫素是一种天然的植物活性成分,主要以其前体萝卜硫苷形式广泛存在于西兰花等十字花科蔬菜中。研究发现,萝卜硫素是非常具有潜力的营养干预物质。萝卜硫素可通过靶向激活转录因子 Nrf2,进而激活下游大于 500个具有细胞保护功能基因的表达,发挥抗氧化、抑制炎症、解毒、抗糖化、免疫调节等多种细胞保护作用。本文综述了萝卜硫素基于营养基因组学的营养干预作用,介绍了萝卜硫素在肿瘤防治、糖尿病干预以及幽门螺杆菌抑制中的应用研究进展。
Abstract:
Sulforaphane is a natural plant active ingredient, which is widely present in cruciferous vegetables such as broccoli, mainly in the form of its precursor sulforaphane. Previous study found that sulforaphane was a very potential nutritional intervention substance. Sulforaphane can activate the transcription factor Nrf2, and then activate the expression of more than 500 genes with cell protection function downstream, which play a variety of cell protection functions such as anti-oxidation, anti-inflammation, detoxification, anti-glycation, and immune regulation. This article reviews the effects of sulforaphane on nutrition intervention based on nutritional genomics and introduces the research progress of sulforaphane in cancer prevention, diabetes intervention and Helicobacter pylori inhibition.

参考文献/References:


[1] 林晓斐 .国务院办公厅印发《中国防治慢性病中长期规划(2017~2025 年)》.中医药管理杂志, 2017, 25(4):14.
[2] Zhang Y, Talalay P, Cho CG, et al. A major inducer of anticarcinogenic protective enzymes from broccoli: isolation and elucidation of structure. Proc Natl Acad Sci USA, 1992, 89(6):2399-2403.
[3] Fahey JW, Zhang Y, Talalay P. Broccoli sprouts: an exceptionally rich source of inducers of enzymes that protect against chemical carcinogens. Proc Natl Acad Sci USA, 1997, 94(19): 10367-10372.
[4] Yang L, Palliyaguru DL, Kensler TW. Frugal chemoprevention:targeting Nrf2 with foods rich in sulforaphane. Semin Oncol,2016, 43(1):146-153.
[5] Pall ML, Levine S. Nrf2, a master regulator of detoxification and also antioxidant, anti-inflammatory and other cytoprotective mechanisms, is raised by health promoting factors. Sheng Li Xue Bao, 2015, 67(1):1-18.
[6] Lewis KN, Mele J, Hayes JD, et al. Nrf2, a guardian of healthspan and gatekeeper of species longevity. Integr Comp Biol, 2010, 50(5):829-843.
[7] Houghton CA, Fassett RG, Coombes JS. Sulforaphane and Other Nutrigenomic Nrf2 Activators: Can the Clinician's Expectation Be Matched by the Reality? Oxid Med Cell Longev, 2016,2016:7857186.
[8] Russo M, Spagnuolo C, Russo GL, et al. Nrf2 targeting by sulforaphane: A potential therapy for cancer treatment. Crit Rev Food Sci Nutr, 2018, 58(8):1391-1405.
[9] Singh AV, Xiao D, Lew KL, et al. Sulforaphane induces caspasemediated apoptosis in cultured PC-3 human prostate cancer cells and retards growth of PC-3 xenografts in vivo. Carcinogenesis,2004, 25(1):83-90.
[10] Kombairaju P, Ma J, Thimmulappa RK, et al. Prolonged sulforaphane treatment does not enhance tumorigenesis in oncogenic K-ras and xenograft mouse models of lung cancer. J Carcinog, 2012,11:8.
[11] Chen YJ, Wallig MA, Jeffery EH. Dietary Broccoli Lessens Development of Fatty Liver and Liver Cancer in Mice Given Diethylnitrosamine and Fed a Western or Control Diet. J Nutr, 2016, 146(3):542-550.
[12] Egner PA, Chen JG, Zarth AT, et al. Rapid and sustainable detoxication of airborne pollutants by broccoli sprout beverage:results of a randomized clinical trial in China. Cancer Prev Res (Phila), 2014, 7(8):813-823.
[13] Lozanovski VJ, Houben P, Hinz U, et al. Pilot study evaluating broccoli sprouts in advanced pancreatic cancer (POUDER trial) -study protocol for a randomized controlled trial. Trials, 2014,15:204.
[14] Liu YW, Liu XL, Kong L, et al. Neuroprotection of quercetin on central neurons against chronic high glucose through enhancement of Nrf2/ARE/glyoxalase-1 pathway mediated by phosphorylation regulation. Biomed Pharmacother, 2019, 109:2145-2154.
[15] Takahashi A, Takabatake Y, Kimura T, et al. Autophagy Inhibits the Accumulation of Advanced Glycation End Products by Promoting Lysosomal Biogenesis and Function in the Kidney Proximal Tubules. Diabetes, 2017, 66(5):1359-1372.
[16] Yamagishi S, Nishino Y, Ojima A, et al. Oral consumption of sulforaphane precursor-rich broccoli supersprouts decreases serum levels of advanced glycation end products in humans. Diabetes Frontier Online, 2015, 2:e1- e011.
[17] Bai Y, Wang X, Zhao S, et al. Sulforaphane Protects against Cardiovascular Disease via Nrf2 Activation. Oxid Med Cell Longev, 2015, 2015:407580.
[18] Cui W, Li B, Bai Y, et al. Potential role for Nrf2 activation in the therapeutic effect of MG132 on diabetic nephropathy in OVE26 diabetic mice. Am J Physiol Endocrinol Metab, 2013, 304(1):87-99.
[19] Bahadoran Z, Tohidi M, Nazeri P, et al. Effect of broccoli sprouts on insulin resistance in type 2 diabetic patients: a randomized double-blind clinical trial. Int J Food Sci Nutr, 2012, 63(7):767-771.
[20] Axelsson AS, Tubbs E, Mecham B, et al. Sulforaphane reduces hepatic glucose production and improves glucose control in patients with type 2 diabetes. Sci Transl Med, 2017, 9(394):eaah4477.
[21] Fahey JW, Haristoy X, Dolan PM, et al. Sulforaphane inhibits extracellular, intracellular, and antibiotic-resistant strains of Helicobacter pylori and prevents benzo[a]pyrene-induced stomach tumors. Proc Natl Acad Sci USA, 2002, 99(11): 7610- 7615.
[22] Haristoy X, Angioi-Duprez K, Duprez A, et al. Efficacy of sulforaphane in eradicating Helicobacter pylori in human gastric xenografts implanted in nude mice. Antimicrob Agents Chemother, 2003, 47(12):3982-3984.
[23] Yanaka A, Fahey JW, Fukumoto A, et al. Dietary sulforaphanerich broccoli sprouts reduce colonization and attenuate gastritis in Helicobacter pylori-infected mice and humans. Cancer Prev Res (Phila), 2009, 2(4):353-360.
[24] Mirmiran P, Bahadoran Z, Golzarand M, et al. A comparative study of broccoli sprouts powder and standard triple therapy on cardiovascular risk factors following H. pylori eradication: a randomized clinical trial in patients with type 2 diabetes. J Diabetes Metab Disord, 2014, 13:64.
[25] Houghton CA. Sulforaphane: Its "Coming of Age" as a Clinically Relevant Nutraceutical in the Prevention and Treatment of Chronic Disease. Oxid Med Cell Longev, 2019:2716870.

备注/Memo

备注/Memo:
作者简介 :潘 宇,副主任医师,医学硕士,从事临床营养研究工作。E-mail:panyu-hai@163.com 通讯作者 :吴伦清,E-mail:381190596@qq.com
更新日期/Last Update: 1900-01-01