[1]葛建超,彭 鲁,郏文亭,等.阿尔茨海默病病人的营养状况与认知功能的关系[J].肠外与肠内营养杂志,2020,(06):345-349.[doi:10.16151/j.1007-810x.2020.06.006]
　GE Jian-chao,PENG Lu,JIA Wen-ting,et al.Comparison of cognitive function in Alzheimer's patients with different nutritional status[J].PARENTERAL & ENTERAL NUTRITION,2020,(06):345-349.[doi:10.16151/j.1007-810x.2020.06.006]
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阿尔茨海默病病人的营养状况与认知功能的关系
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《肠外与肠内营养》杂志[ISSN:1007-810X/CN:32-1477/R]

卷:
期数:
2020年06期
页码:
345-349
栏目:
论著
出版日期:
2020-11-10

文章信息/Info

Title:
Comparison of cognitive function in Alzheimer's patients with different nutritional status
作者:
葛建超1; 彭 鲁 2; 郏文亭3; 张利丽1; 赵 英1; 胡秀秀 1; 董靖德1
1.南京医科大学附属脑科医院老年医学科，江苏南京 210029；2.南京医科大学附属脑科医院检验科，江苏南京 210029；3.南京医科大学附属老年医院，江苏南京 210024
Author(s):
GE Jian-chao1;  PENG Lu2;  JIA Wen-ting3;  ZHANG Li-li1;  ZHAO Ying1;  HU Xiu-xiu1;  DONG Jing-de1
1. Department of Geriatrics, Brain hospital affiliated to Nanjing medical university, Nanjing 210002,Jiangsu, China；2. Department of Laboratory, Brain hospital affiliated to Nanjing medical university,Nanjing 210002, Jiangsu,China；3.Geriatric hospital of Nanjing medical university, Nanjing 210024,Jiangsu,China
关键词:
阿尔茨海默病 ; 营养不良 ; 认知功能
Keywords:
Alzheimer disease;  Malnutrition;  Cognitive function
分类号:
R749.16，R459.3
DOI:
10.16151/j.1007-810x.2020.06.006
文献标志码:
A
摘要:
目的：比较不同营养状况对AD病人的认知功能的影响。 方法：回顾性分析就诊于南京脑科医院的AD病人150例，应用微型营养评估（MNA）评估病人的营养状况；应用简短精神状态量表（MMSE）、临床痴呆评定（CDR）、阿尔茨海默病评定量表-认知（ADAS-Cog）评估病人的认知功能情况；应用日常生活能力量表（ADL）评估病人的日常生活能力；应用神经精神科问卷（NPI）评估病人的精神行为情况。 结果：不同营养状况AD病人的MMSE、ADL、CDR、NPI、ADAS-cog差异有统计学意义；单因素分析发现MMSE（r=0.495，P=0.001）与MNA呈正相关，而病程(r=-0.209，P=0.001)、CDR(r=-0.400，P=0.001)、ADL(r=-0.404，P=0.001)、NPI(r=-0.332，P=0.001)、ADAS cog(-0.436，P=0.001)与MNA呈负相关。二元Logistic回归分析发现MMSE[OR=0.77，95%CI:0.61~0.95, P = 0.031]与营养异常状态显著相关。 结论：营养状态差的AD病人其认知功能下降更显著，日常生活能力损害更严重，伴发精神行为异常的发生率更高。
Abstract:
Objective: To compare the effects of different nutritional status on the cognitive function of Alzheimer's disease (AD) patients. Methods: A retrospective analysis of 150 patients with AD were admitted to Nanjing Brain Hospital. The nutritional status of the patients was evaluated by the Mini Nutritional Assessment (MNA); The patient’s cognitive function was assessed by the Minimum Mental State Examination (MMSE), Clinical Dementia Rating (CDR), and Alzheimer’s Disease Assessment Scale-Cognitive section (ADAS-Cog) ; using the Activity of Daily Living (ADL) to assess the patient’s ability of daily living; using the Neuropsychiatric Inventory (NPI) to assess the patient’s mental behavior Happening. Results: The differences in MMSE, ADL, CDR, NPI, ADAS-cog of AD patients with different nutritional status were statistically significant; Univariate analysis found that MMSE (r=0.495, P=0.001) was positively correlated with MNA, while Course of disease (r=-0.209, P=0.001), CDR (r=-0.400, P=0.001), ADL (r=-0.404, P=0.001), NPI (r=-0.332, P=0.001), ADAS- cog (-0.436, P=0.001) was negatively correlated with MNA. Binary Logistics regression analysis found that MMSE [OR=0.77，95%CI: 0.61~0.95, P = 0.031] was significantly related to abnormal nutritional status. Conclusion: AD patients with poor nutritional status have a more obvious decline in cognitive function, more serious impairment of daily living ability, and higher incidence of abnormal mental behavior.

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备注/Memo

备注/Memo:
基金项目 ：江苏省干部保健科研课题（BJ18003） 作者简介 ：葛建超，主治医师，医学硕士，从事认知障碍方面研究。E-mial：gejch0602@163.com 通讯作者 ：董靖德，E-mial：Dongjingde1978@163.com
更新日期/Last Update: 1900-01-01