[1]吴 剑,陈薇薇,陈旦龙.早期肠内营养联合益生菌在重型颅脑外伤病人中临床价值研究[J].肠外与肠内营养杂志,2020,(02):69-71.[doi:10.16151/j.1007-810x.2020.02.002]
　WU Jian,CHEN Wei-wei,CHEN Dan-long.Clinical value evaluation of early enteral nutrition combined with probiotics in patients with severe traumatic brain injury[J].PARENTERAL & ENTERAL NUTRITION,2020,(02):69-71.[doi:10.16151/j.1007-810x.2020.02.002]
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早期肠内营养联合益生菌在重型颅脑外伤病人中临床价值研究
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《肠外与肠内营养》杂志[ISSN:1007-810X/CN:32-1477/R]

卷:
期数:
2020年02期
页码:
69-71
栏目:
论著
出版日期:
2020-03-10

文章信息/Info

Title:
Clinical value evaluation of early enteral nutrition combined with probiotics in patients with severe traumatic brain injury
作者:
吴 剑; 陈薇薇; 陈旦龙
浙江省台州市第一人民医院神经外科，浙江台州 318020
Author(s):
WU Jian;  CHEN Wei-wei;  CHEN Dan-long
Department of Neurosurgery, The First People's Hospital of Taizhou, Taizhou 318020, Zhejiang,China
关键词:
肠内营养 ; 益生菌 ; 颅脑外伤 ; 临床价值
Keywords:
Enteral nutrition;  Probiotics;  Traumatic brain injury;  Clinical value
分类号:
R651.15
DOI:
10.16151/j.1007-810x.2020.02.002
文献标志码:
A
摘要:
目的：探讨早期肠内营养（EEN）联合益生菌在重型颅脑外伤病人中临床应用价值。 方法：自2015 年8月至2018年5月连续性纳入重型颅脑损伤病人72例，随机分为研究组及对照组，每组各36例。两组均给予 EEN治疗，研究组额外添加益生菌。比较两组病人血清炎症因子、应激激素、肠道粘膜屏障指标以及EN并发症等 差异。 结果：两组一般临床资料未见统计学差异，具有可比性（P > 0.05）。至EN应用第7天，研究组血清肿瘤坏 死因子α（P = 0.034）、C反应蛋白（P = 0.001）及皮质醇（P = 0.038）浓度显著低于对照组；自EN应用第3天起，研究 组血清血管紧张素II、二胺氧化酶及D乳酸浓度显著低于对照组（P < 0.05）。此外，EN应用过程中，研究组胃潴留 （P = 0.023）及下消化道麻痹（P = 0.016）发生率显著低于对照组。 结论：早期EN联合益生菌可有效降低重型颅脑 外伤病人血清炎症因子及应激激素水平，保护肠道粘膜屏障，降低EN并发症。
Abstract:
Objective: To investigate the clinical value of early enteral nutrition (EEN) combined with probiotics in patients with severe traumatic brain injury (TBI). Methods: From August 2015 to May 2018, 72 patients with severe TBI were continuously enrolled and randomly divided into a study group and a control group, each group with 36 cases. Both groups were given early EN treatment, and the study group added probiotics. Serum inflammatory cytokines, stress hormones, intestinal mucosal barrier indicators and EN complications were compared between the two groups. Results: No statistically significant differences were found between groups in general clinical data (P > 0.05). At the 7th day after EN application, serum concentrations of tumor necrosis factor α (P = 0.034), C-reactive protein (P = 0.001) and cortisol (P = 0.038) in the study group were significantly lower than those in the control group. Since the 3rd day of EN application, serum concentrations of angiotensin II, diamine oxidase and D-lactic acid in the study group were significantly lower than those in the control group (all P < 0.05). In addition, incidence of gastric retention (P = 0.023) and lower gastrointestinal paralysis (P = 0.016) was significantly lower in the study group. Conclusion: Early EN combined with probiotics can effectively reduce the level of serum inflammatory factors and stress hormones concentrations, protect the intestinal mucosal barrier, and reduce the incidence of EN complications in severe TBI patients.

参考文献/References:


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备注/Memo

备注/Memo:
作者简介 ：吴 剑，副主任医师，医学本科，从事颅脑创伤救治及神经重症，脑血管病综合治疗。E-mail：15105867812@163.com
更新日期/Last Update: 1900-01-01