[1]苏翔宇,高潺潺,侍方方,等.阿片类药物治疗中重度癌痛病人的营养状况及影响因素分析[J].肠外与肠内营养杂志,2019,(05):261-265.[doi:DOI : 10.16151/j.1007-810x.2019.05.002]
　SU Xiang-yu,GAO Chan-chan,SHI Fang-fang,et al.Nutritional status and its related factors in opioids-treated patients with moderate to severe cancer pain[J].PARENTERAL & ENTERAL NUTRITION,2019,(05):261-265.[doi:DOI : 10.16151/j.1007-810x.2019.05.002]
点击复制

阿片类药物治疗中重度癌痛病人的营养状况及影响因素分析
分享到：

《肠外与肠内营养》杂志[ISSN:1007-810X/CN:32-1477/R]

卷:
期数:
2019年05期
页码:
261-265
栏目:
论著
出版日期:
2019-09-10

文章信息/Info

Title:
Nutritional status and its related factors in opioids-treated patients with moderate to severe cancer pain
作者:
苏翔宇 1; 高潺潺 1; 侍方方 1; 周 良 2; 王彩莲 1
1.东南大学附属中大医院肿瘤科/东南大学医学院，江苏南京210009；2.安徽中医药大学附属滁州中西医结合医院肿瘤科，安徽滁州239000
Author(s):
SU Xiang-yu1;  GAO Chan-chan1;  SHI Fang-fang1;  ZHOU Liang2;  WANG Cai-lian1
1. Department of Oncology，Zhongda Hospital，School of Medicine, Southeast University，Nanjing 210009，Jiangsu, China；2. Department of Oncology，Affiliated Hospital of Integrated Traditional Chinese and Western Medicine，Anhui University of Chinese Medicine，Chuzhou 239000，Anhui，China
关键词:
癌痛 ; 阿片类药物 ; 营养状况 ; 影响因素
Keywords:
Cancer pain;  Opioid;  Nutritional status;  Influencing factor
分类号:
R730.9
DOI:
DOI : 10.16151/j.1007-810x.2019.05.002
文献标志码:
A
摘要:
目的：统计使用阿片类药物止痛的中重度癌痛病人营养不良的发生率，分析影响以上群体病人营养不良的相关因素。 方法：回顾性分析 2013年 7月至 2018年 7月符合纳入标准的中重度癌痛住院病人，通过 NRS2002对其进行营养风险筛查，再评估其营养状况，同时对这些病人的临床资料、癌痛控制情况以及肿瘤治疗情况进行总结，分析影响营养不良的因素。 结果：共 216例中重度癌痛病人纳入研究，其中营养风险发生率 59.3%，营养不良发生率 35.2%，多因素 Logistic回归分析显示疼痛控制情况是影响使用阿片类药物止痛的中重度癌痛病人营养不良的独立危险因素。 结论：使用阿片类药物止痛的中重度癌痛病人营养不良发生率高，特别是疼痛控制不佳的癌痛病人，对于此类病人应及时、积极地给予病人营养支持治疗。
Abstract:
Objective: To investigate the nutritional status in patients suffering from moderate to severe cancer pain treated with opioid analgesics, and to analyze the risk factors associated with malnutrition in this population.Method: We retrospectively analyzed 216 cancer patients enrolled from July 2013 to July 2018. Nutritional risk screening 2002 (NRS 2002) was used to analyze the prevalence of nutritional risk．Nutritional status was determined according to the malnutrition criteria from ESPEN Consensus Statement. Patients’demographics, methods for cancer pain control and the treatment of primary cancer were summarized, and the factors affecting malnutrition were analyzed. Results: A total of 216 patients with moderate to severe cancer pain were included in this study. The incidence of nutritional risk and malnutrition were 59.3% and 35.2%, respectively. Multivariate logistic regression analysis revealed that sufficiency of pain control was independent risk factor for malnutrition in patients with moderate to severe cancer pain. Conclusion: There was a high incidence of malnutrition in patients using opioids with moderate to severe cancer pain. In particular, for cancer patients with poorly pain control, nutritional support should be timely and actively performed.

参考文献/References:


[1] McGuire S. World Cancer Report 2014. Geneva, Switzerland:World Health Organization, International Agency for Research on Cancer, WHO Press, 2015. Adv Nutr, 2016,7(2):418-419.
[2] Huang Y. Current status of pain management in China: an overview. Eur J Pain, 2001,5 Suppl A:67-71.
[3] 李子建, 姚玉昕, 李海龙, 等 . 住院患者肿瘤相关营养不良现况分析:一项横断面调查研究 . 中国临床医生杂志, 2016 , 44 (6) :19-23.
[4] Bally MR, Blaser Yildirim PZ, Bounoure L, et al. Nutritional Support and Outcomes in Malnourished Medical Inpatients: A Systematic Review and Meta-analysis. JAMA Intern Med, 2016,176(1):43-53.
[5] 中国抗癌协会 . 营养风险筛查 . 肿瘤代谢与营养电子杂志,2016 (2) :100-101.
[6] Cederholm T, Bosaeus I, Barazzoni R, et al. Diagnostic criteria for malnutrition - An ESPEN Consensus Statement. Clin Nutr,2015,34(3):335-340.
[7] Paice JA, Ferrell B. The management of cancer pain. CA Cancer J Clin, 2011 , 61(3):157-182.
[8] Breivik H, Cherny N, Collett B, et al. Cancer-related pain: a panEuropean survey of prevalence, treatment, and patient attitudes.Ann Oncol, 2009, 20(8):1420-1433.
[9] Yang YP, Ma YX, Huang Y, et al. The good pain management (GPM) ward program in China and its impact on Chinese cancer patients: the SYSUCC experience. Chin J Cancer, 2014 , 33(7): 323-329.
[10] Argilés JM. Cancer-associated malnutrition. Eur J Oncol Nurs, 2005,9 Suppl 2:S39-S50.
[11] Takahashi H, Chiba T, Tairabune T, et al. A retrospective study on the influence of nutritional status on pain management in cancer patients using the transdermal fentanyl patch. Biol Pharm Bull,2014,37(5):853-857.
[12] 石汉平, 许红霞, 林 宁,等 . 营养不良再认识 . 肿瘤代谢与营养电子杂志, 2015, 2(4) :1-5.
[13] 孙 振, 任熙文, 田字彬, 等 . 恶性肿瘤住院病人营养风险及营养不足发生率调查 . 齐鲁医学杂志, 2015, 30(5) :537-540.
[14] Ma L, Poulin P, Feldstain A, et al. The association between malnutrition and psychological distress in patients with advanced head-and-neck cancer. Curr Oncol, 2013,20(6):e554-560.
[15] Arslan M, Soylu M, Kaner G, et al. Evaluation of malnutrition detected with the Nutritional Risk Screening 2002 (NRS-2002) and the quality of life in hospitalized patients with chronic obstructive pulmonary disease. Hippokratia,2016,20(2):147-152.
[16] Tairabune T, Takahashi H, Chiba T, et al. Effect of nutritional status on transdermal fentanyl absorption in cancer patients. Palliative Care Research, 2012, 7(2):395-402.
[17] Takemura Y, Sasaki M, Goto K, et al. Energy metabolism and nutritional status in hospitalized patients with lung cancer. J Clin Biochem Nutr, 2016,59(2):122-129.
[18] 罗智鹏, 石华伟, 薛瑶纯, 等 . 常见恶性肿瘤住院病人营养状态的调查和分析 .肠外与肠内营养,2016,23(3):162-169.
[19] Chi J, Yin S, Zhu Y, et al. A Comparison of the Nutritional Risk Screening 2002 Tool With the Subjective Global Assessment Tool to Detect Nutritional Status in Chinese Patients Undergoing Surgery With Gastrointestinal Cancer. Gastroenterol Nurs, 2017,40(1):19-25.
[20] Vidra N, Smarina F, Migdanis A, et al. The impact of chronic pain in nutritional status and prognosis of patients with metastatic cancer primaries. Clin Nutr ESPEN,2016,13:e60.
[21] Chabowski M, Polański J, Jankowska-Polańska B, et al. Is nutritional status associated with the level of anxiety, depression and pain in patients with lung cancer? J Thorac Dis, 2018 ,10(4):2303-2310.
[22] Huang R, Jiang L, Cao Y, et al. Comparative Efficacy of Therapeutics for Chronic Cancer Pain: A Bayesian Network MetaAnalysis. J Clin Oncol, 2019,37(20):1742-1752.
[23] Smith EML. Pharmacologic Treatments for Chronic Cancer-Related Pain: Does Anything Work?. J Clin Oncol, 2019,37(20):1686-1689.

备注/Memo

备注/Memo:
作者简介 ：苏翔宇，主治医师，医学博士，从事消化系恶性肿瘤综合治疗工作。E-mail：suxiangyu1982@.126com 通讯作者 ：王彩莲，E-mail：wangcailian65@hotmail.com
更新日期/Last Update: 1900-01-01