[1]齐 鹏,罗旭东.多种油脂肪乳注射液在新生儿营养支持中的临床应用研究进展[J].肠外与肠内营养杂志,2024,(05):312-316320.
　QI Peng,LUO Xu-dong.Advances in clinical application of muti-oil fat emulsion in neonatalnutritional support[J].PARENTERAL & ENTERAL NUTRITION,2024,(05):312-316320.
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多种油脂肪乳注射液在新生儿营养支持中的临床应用研究进展()
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《肠外与肠内营养》杂志[ISSN:1007-810X/CN:32-1477/R]

卷:
期数:
2024年05期
页码:
312-316320
栏目:
综述
出版日期:
2024-10-10

文章信息/Info

Title:
Advances in clinical application of muti-oil fat emulsion in neonatalnutritional support
作者:
齐 鹏1; 罗旭东2
1.甘肃省妇幼保健院/甘肃省中心医院药学部，甘肃兰州 730000；2. 甘肃中医药大学药学院，甘肃兰州 730000
Author(s):
QI Peng1;  LUO Xu-dong2
1. Department of Pharmacy, Gansu Provincial Central Hospital / Gansu Provincial Maternal andChild Health Hospital, Lanzhou 730000, Gansu, China；2.College of Pharmacy, Gansu University ofChinese Medicine, Lanzhou 730000, Gansu, China.
关键词:
多种油脂肪乳 ; 营养支持 ; 肠外营养 ; 新生儿
Keywords:
Multi-oil fat emulsion;  Nutritional support;  Parenteral nutrition;  Neonate
分类号:
R459.3-61
文献标志码:
A
摘要:
脂肪乳注射液是肠外营养支持治疗中的重要组成部分，可为人体提供更均衡的能量和必需脂肪酸。多种油脂肪乳是适用于儿科的含鱼油的脂肪乳注射液，其含有更多的维生素 E 和更少的植物甾醇，二十碳五烯酸、二十二碳六烯酸含量更高，抗炎性更强。此外，其脂肪酸谱与母乳接近，能够为新生儿提供更均衡高效的营养支持。目前多种油脂肪乳已广泛应用于临床，但国内关于多种油脂肪乳注射液在新生儿临床应用方面的研究报道较少，因此本文对多种油脂肪乳注射液在新生儿营养支持方面的临床研究进展进行了综述。
Abstract:
Fat emulsion injection is an important component of parenteral nutritional support therapy, providingthe body with a more balanced supply of energy and essential fatty acids. Multi-oil lipid emulsions are fish oil-containinglipid emulsions suitable for pediatric use. They contain higher levels of vitamin E and lower levels of phytosterols, aswell as increased amounts of eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), contributing to strongeranti-inflammatory properties. Furthermore, their fatty acid profile closely resembles that of human breast milk, enablingthem to provide more balanced and effective nutritional support for neonates. While multi-oil lipid emulsions have beenwidely used clinically, there are limited research reports on their application in neonates in China. This article reviews theprogress of clinical research on the application of multi-oil lipid emulsions in neonatal nutritional support.

参考文献/References:


[1] Haines KL, Ohnuma T, Trujillo C, et al. Hospital change to mixedlipid emulsion from soybean oil-based lipid emulsion forparenteral nutrition in hospitalized and critically ill adultsimproves outcomes: a pre-post-comparative study[J]. Crit Care,2022, 26(1): 317.
[2] Kulpins D, Pickney C, Garb M, et al. Neonatal intensive care unitmixed lipid emulsion use associated with reduced cholestasis atdischarge in surgical patients[J]. J Surg Res, 2023, 287: 1-7.
[3] Martínez-Lozano Aranaga F, Gómez Ramos MJ, Sánchez ?lvarezMDC.Effectiveness and safety of two lipid emulsions for parenteralnutrition in postsurgical critically ill patients: Clinoleic? versusSMOFlipid?[J]. Nutr Hosp. 2021, 38(1): 5-10.
[4] Yu LJ, Anez-Bustillos L, Mitchell PD, et al. Incidence anddevelopment of cholestasis in surgical neonates receiving anintravenous mixed-oil lipid emulsion[J]. JPEN J Parenter EnteralNutr, 2023, 47(1): 30-40.
[5] 张 田,王学阳,倪 倩,等 . 新型多种油脂肪乳注射液在早产儿肠外营养支持中的系统评价[J]. 中华临床营养杂志, 2018,26(6):354-360.
[6] Rogulska J, Osowska S, Kunecki M, et al. Antioxidant balance inplasma of patients on home parenteral nutrition: A pilot studycomparing three different lipid emulsions[J]. Clinical Nutrition,2021, 40(6): 3950-3958.
[7] Nilsson AK, L?fqvist C, Najm S, et al. Influence of human milkand parenteral lipid emulsions on serum fatty acid profiles inextremely preterm infants[J]. JPEN J Parenter Enteral Nutr, 2019,43(1): 152-161.
[8] Kilicbay F, Keskin A, Gunlemez A. Effects of fish oil(SMOFlipid?) and olive oil lipid (ClinOleic?) on neonatalmorbidities in preterm infants[J]. Medeni Med J, 2022, 37(3):240-247.
[9] Combs, Gerald F, The vitamins: fundamental aspects in nutritionand health[M]. boston: elsevier academic press, 2008.
[10] Reginald HG, Charles MG. Biochemistry[Z]. 2008.
[11] Patel JK, Rouster AS. Infant Nutrition Requirements and Options[Z]. 2023.
[12] 杨冠聪, 朱江华, 赵 颖, 等 . 添加多种油脂肪乳在早产儿全静脉营养中的价值和安全性研究[J]. 中国实用医药, 2020, 15(29): 17-19.
[13] Bin-Nun A, Kassirer Y, Mimouni FB, et al. Head circumferencegrowth is enhanced by SMOFlipid in preterm neonates[J]. Am JPerinatol, 2020, 37(11): 1130-1133.
[14] 顾兆丹, 王永芹, 刘 茜, 等 . 早产儿应用多种油脂肪乳与中长链脂肪乳疗效比较[J]. 潍坊医学院学报, 2022, 44(1): 45-47.
[15] Mihatsch WA, Braegger C, Bronsky J, et al. ESPGHAN/ESPEN/ESPR/CSPEN guidelines on pediatric parenteral nutrition[J]. ClinNutr, 2018, 37(6 Pt B): 2303-2305.
[16] Dankhara N, Holla I, Ramarao S, et al. Bronchopulmonarydysplasia: pathogenesis and pathophysiology[J]. J Clin Med,2023, 12(13): 4207.
[17] Shukla VV, Ambalavanan N. Recent advances inbronchopulmonary dysplasia[J]. Indian J Pediatr, 2021, 88(7):690-695.
[18] 林佳佳, 刘素佳, 欧阳夏, 等 . 超低出生体质量儿应用多种油脂肪乳与中长链脂肪乳的效果[J]. 中国卫生标准管理, 2021, 12(18): 96-99.
[19] Tenorio-Lopes L, Baldy C, Jochmans-Lemoine A, et al.Consequences of maternal omega-3 polyunsaturated fatty acidsupplementation on respiratory function in rat pups[J]. J Physiol,2017, 595(5): 1637-1655.
[20] Lavoie JC, Mohamed I, Nuyt AM, et al. Impact of SMOFLipid onpulmonary alveolar development in newborn Guinea Pigs[J].JPEN J Parenter Enteral Nutr, 2018, 42(8): 1314-1321.
[21] Uberos J, Jiménez-Montilla S, Molina-Oya M, et al. Morbidityoutcomes of very low birth weight neonates receiving parenteralnutrition with fish oil enriched lipid emulsion or lipid emulsionwith soybean oil: an observational study[J]. Am J Perinatol, 2021,38(9): 952-959.
[22] Asfour SS, Alshaikh B, AlMahmoud L, et al. SMOFlipid impacton growth and neonatal morbidities in very preterm infants[J].Nutrients, 2022, 14(19): 3952.
[23] Wang YL, Chen LJ, Tsao LY, et al. Parenteral nutrition with fishoil-based lipid emulsion reduces the risk of cholestasis in preterminfants[J]. J Int Med Res, 2021, 49(5): 3000605211011805.
[24] Deshpande GC, Cai W. Use of lipids in neonates requiringparenteral nutrition[J]. JPEN J Parenter Enteral Nutr, 2020, 44Suppl 1: S45-S54.
[25] 孙 僮, 富建华 . 早产儿胃肠外营养相关性胆汁淤积症的危险因素及防治进展[J]. 中华新生儿科杂志, 2021, 36(5):68-71.
[26] Christensen RD, Henry E, Wiedmeier SE, et al. Identifyingpatients, on the first day of life, at high-risk of developingparenteral nutrition-associated liver disease[J]. J Perinatol, 2007,27(5): 284-290.
[27] Al-Alaiyan S, Elsaidawi W, Alanazi AM, et al. Ursodeoxycholicacid and SMOFlipid for treating parenteral nutrition associatedcholestasis in infants[J]. Cureus, 2022, 14(2): e22060.
[28] Wang C, Venick RS, Shew SB, et al. Long-Term outcomes inchildren with intestinal Failure-Associated liver disease treatedwith 6 months of intravenous fish oil followed by resumption ofintravenous soybean oil[J]. JPEN J Parenter Enteral Nutr, 2019,43(6): 708-716.
[29] Gura KM, Premkumar MH, Calkins KL, et al. Fish oil emulsionreduces liver injury and liver transplantation in children withintestinal Failure-Associated liver disease: a multicenterintegrated study[J]. J Pediatr, 2021, 230: 46-54.e2.
[30] 林慧佳,沈晓霞,倪映华，等 . 多种油脂肪乳在超低出生体重儿中应用的疗效分析 . 中国当代儿科杂志,2021,23(3):229-235.
[31] Kasirer Y, Bin-Nun A, Raveh A, et al. SMOFlipid protectspreterm neonates against perinatal Nutrition-Associatedcholestasis[J]. Am J Perinatol, 2019, 36(13): 1382-1386.
[32] 段玉会, 张霞, 王岩, 等 . 多种油脂肪乳在早产儿肠外营养中应用 及 对 营 养 状 态 影 响 [J]. 临 床 军 医 杂 志 , 2023, 51(4): 414-416, 420.
[33] 中华医学会眼科学分会眼底病学组 . 中国医师协会眼科医师分会眼底病专委会 . 中国早产儿视网膜病变分类和治疗专家共识[J]. 中华眼底病杂志, 2023, 39(9): 720-727.
[34] Martindale RG, Klek S. Lipids in parenteral nutrition:introduction[J]. JPEN J Parenter Enteral Nutr, 2020, 44 Suppl 1:S5-S6.
[35] McCann JC, Ames BN. Is docosahexaenoic acid, an n-3 longchain polyunsaturated fatty acid, required for development ofnormal brain function? An overview of evidence from cognitiveand behavioral tests in humans and animals[J]. Am J Clin Nutr,2005, 82(2): 281-295.
[36] Baack ML, Puumala SE, Messier SE, et al. What is therelationship between gestational age and docosahexaenoic acid(DHA) and arachidonic acid (ARA) levels? [J]. ProstaglandinsLeukot Essent Fatty Acids, 2015, 100: 5-11.
[37] Hill NS, Cormack BE, Herbison K, et al. A clinical audit ofgrowth and clinical outcome in very low birthweight babies at theAuckland city hospital neonatal intensive care unit before andafter the introduction of SMOFlipid[J]. Transplantation, 2017, 101(6S2): S13.
[38] Gharehbaghi G, Mohagheghi P, Sedaghat A, et al. Parenteral FishOil lipid emulsions in retinopathy of prematurity: a retrospectivecomparative study[J]. J Curr Ophthalmol, 2020, 32(1): 69-74.
[39] Kamino D, Studholme C, Liu MY, et al. Postnatalpolyunsaturated fatty acids associated with larger preterm braintissue volumes and better outcomes[J]. Pediatr Res, 2018, 83(1/1): 93-101.
[40] Massari M, Novielli C, Mandò C, et al. Multiple micronutrientsand docosahexaenoic acid supplementation during pregnancy: arandomized controlled study[J]. Nutrients, 2020, 12(8): 2432.
[41] Mallick R, Basak S, Duttaroy AK. Docosahexaenoic acid,22:6n-3: Its roles in the structure and function of the brain[J]. Int J DevNeurosci, 2019, 79: 21-31.
[42] Chen IL, Hung CH, Huang HC. Smoflipid is better thanlipofundin for Long-Term neurodevelopmental outcomes inpreterm infants[J]. Nutrients, 2021, 13(8): 2548.
[43] Belza C, Wales JC, Courtney-Martin G, et al. An observationalstudy of smoflipid vs intralipid on the evolution of intestinalFailure-Associated liver disease in infants with intestinal failure[J]. JPEN J Parenter Enteral Nutr, 2020, 44(4): 688-696.
[44] Stramara L, Hernandez L, Bloom BT, et al. Development ofparenteral Nutrition-Associated liver disease and other adverseeffects in neonates receiving SMOFlipid or intralipid[J]. JPEN JParenter Enteral Nutr, 2020, 44(8): 1530-1534.
[45] Nutrition NP. London: national institute for health and careexcellence(Nice)[Z] , 2020.
[46] 中华医学会肠外肠内营养学分会 . 鱼油脂肪乳剂临床应用中国专家共识（2022 版）[J]. 中华消化外科杂志, 2022, 21(10): 1313-1325.
[47] Schlegelmilch M, Feder J, Creery D. Inadvertent acute lipidinjectable emulsion overdose resulting in fat overload syndromeand pancreatitis in a patient with TPN dependence[J]. JPGN Rep,2022, 3(1): e146.
[48] 张 婷,马 鸣 . 儿童肠外营养液过敏反应个案报告并文献复习[J]. 肠外与肠内营养, 2022, 29(6): 380-384.
[49] 林 娟,施 欣,刘利婷,等 . 多种油脂肪乳致新生儿乳酸酸中毒和（或）血小板减少两例并文献复习 . 新医学, 2023, 54 (8):580-584.
[50] Low JM, Loh TP, Amin Z. SMOFlipid causing spuriously highserum total bilirubin in an extremely premature neonate[J].Pathology, 2021, 53(5): 685-687.
[51] 成 彧, 李 菁 . 防治早产儿肠外营养相关并发症的研究进展[J]. 肠外与肠内营养, 2015(1): 53-56.

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备注/Memo

备注/Memo:
作者简介 ：齐 鹏，主管药师，药学硕士，主要从事肠外营养及药代动力学研究。E-mail: 15128856725@163.com通讯作者 ：罗旭东，E-mail: luoxudong56@163.com
更新日期/Last Update: 1900-01-01